Commissioned reports, panel and committee contributions, and frameworks

US National Academies

Review of U.S. EPA's ORD Staff Handbook for Developing IRIS Assessments (2022)

At the request of the EPA, this report reviews the procedures and considerations for operationalizing the principles of systematic reviews and the methods described in the handbook for determining the scope of the IRIS assessments, evidence integration, extrapolation techniques, dose-response analyses, and characterization of uncertainties. Read here.

WHO Chemical Risk Assessment Network

Framework for the use of SR in chemical risk assessment (2021)

High-level guidance for chemical risk assessors who are not currently familiar with systematic approaches. Intended to help the reader understand assessments conducted by institutions that have used systematic approaches, and assist in understanding the issues, limitations and challenges involved if institutions are considering using SR approaches themselves. Read here.

Improving the safety of pesticides in the EU

White paper collaboration between NGOs, lawyers, and academics (2018)

Convened by Pesticides Action Network, this White Paper describes in detail a range of issues with how scientific evidence is aggregated, analysed, and acted upon in the regulation of pesticides. A range of ways in which the situation can be improved, including use of SR methods in pesticide evaluations, are articulated. It can be read here, and the resulting manuscript is here.

The future of evidence in chemicals policy

Early white paper on the use of SR in chemical risk assessment (2013)

This report was funded by the European Environment and Health Initiative, to look in detail at how uptake of systematic review methods might improve risk assessment. By now it will look a bit naive, but at the time it was arguably the first detailed presentation of the concept of SR in risk assessment, with an impactful critique of the methods being used for risk assessing bisphenol-A. Read here.